New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish
نویسندگان
چکیده
Department of Chemistry, Imperial College 2AZ, UK. E-mail: [email protected] Institute of Chemical Biology, Imperial Colle 2AZ, UK. E-mail: [email protected] National Heart and Lung Institute, Imperial SW7 2AZ, UK Department of Life Sciences, Imperial Colle 2AZ, UK † Electronic supplementary information ( full experimental details and procedures, 1 1–6. See DOI: 10.1039/c4sc01600a Cite this: Chem. Sci., 2014, 5, 4249
منابع مشابه
New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish† †Electronic supplementary information (ESI) available: Tables S1–S2; Fig. S1–S9, full experimental details and procedures, 1H/13C NMR spectral data of compounds 1–6. See DOI: 10.1039/c4sc01600a Click here for additional data file.
Sonic Hedgehog protein (Shh) is a morphogen molecule important in embryonic development and in the progression of many cancer types in which it is aberrantly overexpressed. Fully mature Shh requires attachment of cholesterol and palmitic acid to its C- and N-termini, respectively. The study of lipidated Shh has been challenging due to the limited array of tools available, and the roles of these...
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